Functional impacts of the diversity of the meningococcal factor H binding protein

► Diversity of fHbp protein, a component of new recombinant anti-meningococci vaccines. ► Diversity of fHbp is encountered even among highly related meningococcal isolates. ► Diversity of fHbp impacts on binding of human factor H and complement activation. ► Correlation between antibody dependant bacterial lysis and expression level of fHbp.