کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10966915 | 1102798 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination
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کلمات کلیدی
PBMCSEBFHAStaphylococcus enterotoxin BBordetella pertussis - بوردتلا پرتوزیسMemory T cell - حافظه T سلولperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیpertussis toxin - سموم سورافنیFilamentous hemagglutinin - هموگلوتینین رشته ایAcellular pertussis vaccine - واکسن کوسه ای ساکولاWhole-cell pertussis vaccine - واکسن کوسه عصبی کل سلولیImmune response - پاسخ یا واکنش ایمنیChildren - کودکانacellular pertussis - کوفتگی زرد
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To better understand vaccine-induced protection and its potential failure in light of recent whooping cough resurgence, we evaluated quantity as well as quality of memory T cell responses in B. pertussis-vaccinated preadolescent children. Using a technique based on flow cytometry to detect proliferation, cytokine production and phenotype of antigen-specific cells, we evaluated residual T cell memory in a cohort of preadolescents who received a whole-cell pertussis (wP; n = 11) or an acellular pertussis vaccine (aP; n = 13) during infancy, and with a median of 4 years elapsed from the last pertussis booster vaccine, which was aP for all children. We demonstrated that B. pertussis-specific memory T cells are detectable in the majority of preadolescent children several years after vaccination. CD4+ and CD8+ T cell proliferation in response to pertussis toxin and/or filamentous hemagglutinin was detected in 79% and 60% of the children respectively, and interferon-γ or tumor necrosis factor-α producing CD4+ T cells were detected in 65% and 53% of the children respectively. Phenotyping of the responding cells showed that the majority of antigen-specific cells, whether defined by proliferation or cytokine production, were CD45RAâCCR7â effector memory T cells. Although the time since the last booster vaccine was significantly longer for wP-compared to aP-vaccinated children, their proliferation capacity in response to antigenic stimulation was comparable, and more children had a detectable cytokine response after wP- compared to aP-vaccination. This study supports at the immunological level recent epidemiological studies indicating that infant vaccination with wP induces longer lasting immunity than vaccination with aP-vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 32, Issue 1, 17 December 2013, Pages 111-118
Journal: Vaccine - Volume 32, Issue 1, 17 December 2013, Pages 111-118
نویسندگان
Kaatje Smits, Gaelle Pottier, Julie Smet, Violette Dirix, Françoise Vermeulen, Iris De Schutter, Maria Carollo, Camille Locht, Clara Maria Ausiello, Françoise Mascart,