Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: Current genotyping of EV71 does not reflect their antigenicity

► To know the difference between antigenicity and genotype of EV71 clinical isolates. ► MAb panel was used to group EV71 isolates based on its reactive profile. ► One class of mAbs which can neutralize all the EV71 isolates was identified. ► We found that current genotyping of EV71 does not reflect their antigenicity. ► This panel of neutralizing mAbs is useful to the selection of EV71 vaccine strain.