Immunological complex for enhancement of innate immune response in passive vaccination

► An immune complex (Y-complex) was designed for targeting innate immune response toward disease agents. ► Mastitis is a major disease in milking cows. ► The passive vaccination successfully eliminates mastitis caused by E. coli and S. dysgalactiae. ► Y-complex shows advantages over antibiotic in treatment of mastitis. ► Y-complex strategy may be applied for treatment of various diseases.