Immunization with the Leishmania infantum recombinant cyclophilin protein 1 confers partial protection to subsequent parasite infection and generates specific memory T cells

- Cyclophilin protein 1 expressed during L. infantum development is located in the cytoplasm.
- Immunization by LirCyP1 promotes the specific differentiation of helper and cytotoxic memory T cells.
- T cells from immunized and challenged mice differentiated in memory subsets after recall by parasite antigens.
- Immunization with LirCyP1 confers high protection levels to L. infantum challenge.
- LirCyP1 represents a new potential vaccine against zoonotic visceral leishmaniosis.