Helicobacter pylori thiolperoxidase as a protective antigen in single- and multi-component vaccines

► Helicobacter pylori thiolperoxidase was a protective systemic vaccine antigen. ► H. pylori thiolperoxidase was a protective mucosal vaccine antigen. ► Vaccinating with a combination of antioxidant enzymes did not improve protection. ► The immunogenicity of individual antigens was reduced when given in combination via the nasal route.