History of the restoration of adenovirus type 4 and type 7 vaccine, live oral (Adenovirus Vaccine) in the context of the Department of Defense acquisition system

► FDA licensed vaccine prevented adenovirus disease in military trainees until 1999. ► Without vaccine to protect trainees, disease, mainly due to serotype 4, returned. ► DoD medical leadership became convinced of the need to restore the vaccine. ► Following vaccine deployment, adenovirus type 4 transmission was interrupted. ► Sustainment of the vaccine in the future remains a formidable challenge.