Strain dependent protection conferred by Lactobacillus spp. administered orally with a Salmonella Typhimurium vaccine in a murine challenge model

► Two Lactobacillus strains were studied for use as adjuvants in a heat-killed Salmonella Typhimurium vaccine challenge model. ► Lactobacillus fermentum PC2 inclusion in the vaccine program led to enhanced humoral antibody responses. ► L. fermentum PC2, which demonstrated higher coaggregation index in vitro afforded better in vivo protection. ► Both Lactobacillus strains exhibited similar binding to Peyer's patches in vitro.