In vitro assessment of halobacterial gas vesicles as a Chlamydia vaccine display and delivery system

► Gas vesicles (Gv) display Chlamydia proteins as part of their membrane structures. ► Recombinant gas vesicles (r-Gv) are readily recognized by human immune sera. ► Gv engage TLRs and stimulate proinflammatory cytokines in a peptide-specific manner. ► Temporal degradation of Gv in vitro, culminates in antigen display at cell surface. ► R-Gv promise to be an ideal multisubunit vaccine display/delivery platform.