The extradomain A of fibronectin (EDA) combined with poly(I:C) enhances the immune response to HIV-1 p24 protein and the protection against recombinant Listeria monocytogenes-Gag infection in the mouse model

► EDA has an immunomodulatory role as fusion protein with anti-viral and anti-tumoral antigens. ► Its adjuvant value with HIV p24 antigens was evaluated in the mouse model. ► EDAp24 with poly(I:C) were immunogenic and efficient against heterologous Lm-Gag challenge.