Scientific investigations into febrile reactions observed in the paediatric population following vaccination with a 2010 Southern Hemisphere Trivalent Influenza Vaccine

► CSL TIVs, as a class, induce greater cytokines/gene signatures compared to other licensed TIVs. ► New H1N1 and B strains in Fluvax 2010 contribute to a further increase in cytokine signal. ► Febrile events by paediatric Fluvax 2010 likely due to: ► Introduction of new 2010 Influenza strains. ► Differences in the manufacturing process as compared to other licensed TIVs.