Plasma beads loaded with Candida albicans cytosolic proteins impart protection against the fungal infection in BALB/c mice

► Development of autologous clotted plasma-based beads as an antigen delivery system. ► Plasma bead entrapped Candida cytosolic proteins evoke specific immune response in the model animals. ► Liposomized Candida antigens further entrapped in the plasma beads elicit both humoral as well as cell mediated immunity. ► The antigen entrapped in the novel vehicle imparts remarkable prophylaxis against virulent C. albicans infection in Balb/c mice.