Nanoemulsion W805EC improves immune responses upon intranasal delivery of an inactivated pandemic H1N1 influenza vaccine

► The effect of nanoemulsions on intranasal influenza vaccination was examined in mice. ► The W805EC nanoemulsion is identified as a candidate mucosal vaccine adjuvant. ► W805EC nanoemulsion improved antibody responses following intranasal vaccination. ► Vaccines with the W805EC nanoemulsion reduced morbidity after influenza challenge.