Bovine respiratory syncytial virus ISCOMs-Immunity, protection and safety in young conventional calves

► BRSV-ISCOMs induce strong clinical and virological protection in young conventional calves with BRSV-specific maternal antibodies. ► Protection is associated with local and systemic humoral responses as well as T cell responses dominated by IFNγ production. ► Animals that did not shed virus detectable by PCR or cell culture following challenge possessed particularly high levels of pulmonary IgA.