Reactogenicity of two 2010 trivalent inactivated influenza vaccine formulations in adults

► In 2010 CSL influenza vaccine was linked to increased febrile adverse events in children. ► We compared the reactogenicity of the 2010 CSL influenza vaccine to another brand among adults. ► Swelling and muscle pain were significantly more common among adults who received CSL vaccine. ► Increased reactions in both children and adults suggests the potential for a common causal pathway.