A recombinant Bacille Calmette-Guérin construct expressing the Plasmodium falciparum circumsporozoite protein enhances dendritic cell activation and primes for circumsporozoite-specific memory cells in BALB/c mice

► BCG-CS induced superior activation of antigen-presenting cells (APCs). ► BCG-CS induced CS-specific antibody responses. ► BCG-CS induced strong CS-specific T-cell responses. ► The response is polarized towards TH1 type immunity. ► BCG-CS is highly efficient in activating APCs for priming of adaptive immunity.