Intraperitoneal immunization of recombinant HSP70 (DnaK) of Salmonella Typhi induces a predominant Th2 response and protective immunity in mice against lethal Salmonella infection

► We investigated the protective efficacy of rHSP70 against lethal Salmonella infection. ► Results revealed that HSP70 immunization significantly increased IgG1 and IgG2a. ► Lymphocyte proliferation, Th2 and Th1 cytokines were also increased significantly. ► HSP70 was found to be immunogenic and protective even without adjuvants. ► Immunization of rHSP70 conferred 70-90% protection against Salmonella infection.