Acute disseminated encephalomyelitis following influenza vaccination

► We present a case of post-vaccination acute disseminated encephalomyelitis (ADEM) following seasonal influenza vaccination. ► We perform a literature review on previously published cases of post-influenza vaccination ADEM. ► Physicians should be made aware of this rare but serious adverse event. ► Most cases display complete recovery. ► Brainstem dysfunction may serve as a poor prognostic indicator.