Early immune responses in Atlantic salmon (Salmo salar L.) after immunization with PLGA nanoparticles loaded with a model antigen and β-glucan

► PLGA possess adjuvant properties. ► Antigen and β-glucan co-entrapped in PLGA NPs. ► Sampled from lymphoid tissues after i.p.-injection in Atlantic salmon. ► Pro-inflammatory and T cell cytokines, effector molecules and transcription factor responses evaluated by Q-PCR. ► PLGA NPs have adjuvant properties in Atlantic salmon.