Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine

► We show the immunologic responses to a species-specific pneumococcal whole cell vaccine administered with aluminum hydroxide. ► Antibody elicited by the vaccine cross-reacts to a panel of clinical pneumococcal isolates of diverse MLST and serotypes. ► Immunization with this vaccine primes T cells to produce robust IL-17A responses to pneumococci regardless of serotype. ► This data suggest broad responses and provide further support for the clinical development of this vaccine.