Identification and characterization of Borrelia antigens as potential vaccine candidates against Lyme borreliosis

► Identification of 122 Borrelia antigens associated with Lyme borreliosis. ► Selection of 15 promising vaccine candidates based on in vitro validation. ► Cross reactive immune response of Borrelia antigens in mice. ► Cytokine response to Borrelia vaccine candidates observed after Borrelia infection of mice.