کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10968872 | 1102911 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and immunogenicity of a Helicobacter pylori lipopolysaccharide-based conjugate
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Helicobacter pylori infection in humans is responsible for the onset of severe gastric disorders and a vaccine would be an improvement over current antibiotic-based treatments. Lipopolysaccharide (LPS; O-chain PS â core â lipid A) is a main H. pylori cell wall component, whose O-chain PS exhibits molecular mimicry and therefore any LPS-based vaccine cannot contain O-chain epitopes. Here, the conjugation of de-lipidated H. pylori O:2 LPS to BSA and its immunogenicity in mice is described. IgG antibodies were observed to recognize the LPSs of representative H. pylori serotypes O:1, O:2 and O:5, and more significantly, the core region of H. pylori. This study showed that a monovalent H. pylori LPS conjugate can elicit antibodies that recognize other serotype-specific H. pylori LPSs and specifically the structurally conserved LPS inner-regions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 29, Issue 17, 12 April 2011, Pages 3098-3102
Journal: Vaccine - Volume 29, Issue 17, 12 April 2011, Pages 3098-3102
نویسندگان
Mario A. Monteiro, Stacey Britton, Lisa A. Applebee, Shahida Baqar,