High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors

► Inhibition of p38 MAPK increases transduction efficiency of moDCs by AAV2 vectors. ► Mutagenesis of serine residues increases transduction efficiency of moDCs by AAV2. ► Transduction of moDCs by mutant AAV2 does not induce phenotypic changes in these cells. ► DCs transduced with mutant AAV2 encoding a human telomerase stimulates specific CTLs.