Invasive pneumococcal diseases in birth cohorts vaccinated with PCV-7 and/or PHiD-CV in the province of Quebec, Canada

► The 10-valent pneumococcal conjugate vaccine was introduced in 2009 in Quebec. ► We present the first data on the effectiveness of this vaccine. ► Invasive pneumococcal disease rates were lower in cohorts exposed to PHiD-CV as compared to PCV-7. ► There was no vaccine-type case following ≥2 PHiD-CV primary doses or one booster dose. ► Results are compatible with high level of protection against IPD caused by homologous serotypes.