Prevention of tick-borne encephalitis by FSME-IMMUN® vaccines: Review of a clinical development programme

► This review summarizes findings of the clinical development programme. ► Vaccination in adults, children and adolescents, the elderly and special patient populations. ► Determination of the optimal dose, conventional and rapid schedules, safety, immunopersistence. ► Comprehensive research programme demonstrated strong immunogenicity and safety of FSME-IMMUN®. ► An effective and well-tolerated solution to the endemic risk of TBE virus infection.