A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines

► A rapid method for VLP vaccine preparation comprising bacterial expression and in vitro self assembly is reported. ► Chimeric VLPs and capsomeres displaying antigen from Streptococcus and influenza are evaluated. ► VLPs induce high antibody response with no significant improvement due to adjuvant. ► Capsomeres are immunogenic and response is improved with adjuvant.