A bivalent vaccine to protect against Streptococcus pneumoniae and Salmonella typhi

► Fusion conjugates are protein-TLR agonist fusions coupled to polysaccharides (PS). ► Salmonella typhi Vi PS and pneumococcal wall PS were coupled to pneumococcal fusions. ► High-titer Vi antibody opsonic to S. typhi was elicited in mice. ► The induced IL17 and antibody prevented murine pneumococcal colonization and sepsis. ► This bivalent combination may immunize infants vs. typhoid and pneumococcal diseases.