کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10969694 1102981 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Telemetric analysis to detect febrile responses in mice following vaccination with a live-attenuated virus vaccine
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Telemetric analysis to detect febrile responses in mice following vaccination with a live-attenuated virus vaccine
چکیده انگلیسی
Non-human primates (NHP) are considered to be the most appropriate model for predicting how humans will respond to many infectious diseases. Due to ethical and monetary concerns associated with the use of NHP, rodent models that are as predictive of responses likely to be seen in human vaccine recipients are warranted. Using implanted telemetry devices, body temperature and activity were monitored in inbred and outbred mouse strains following administration of the live-attenuated vaccine for Venezuelan equine encephalitis virus (VEEV), V3526. Following analysis of individual mouse data, only outbred mouse strains showed changes in diurnal temperature and activity profiles following vaccination. Similar changes were observed following VEEV challenge of vaccinated outbred mice. From these studies, we conclude, outbred mouse strains implanted with telemeters are a sensitive model for predicting responses in humans following vaccination.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issue 49, 16 November 2009, Pages 6814-6823
نویسندگان
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