Efficacy of live attenuated vaccines against 2009 pandemic H1N1 influenza in ferrets

► A single intranasal dose of pH1N1-LAIV confers profound protection against 2009 pandemic H1N1 influenza in intratracheally-inoculated ferrets. ► pH1N1-LAIVs from different manufacturers tested are equally immunogenic and efficacious. ► This LAIV concept has high potential for pandemic preparedness.