کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10969799 | 1102993 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Incorporation of immunostimulatory motifs in the transcribed region of a plasmid DNA vaccine enhances Th1 immune responses and therapeutic effect against Mycobacterium tuberculosis in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Incorporation of immunostimulatory motifs in the transcribed region of a plasmid DNA vaccine enhances Th1 immune responses and therapeutic effect against Mycobacterium tuberculosis in mice Incorporation of immunostimulatory motifs in the transcribed region of a plasmid DNA vaccine enhances Th1 immune responses and therapeutic effect against Mycobacterium tuberculosis in mice](/preview/png/10969799.png)
چکیده انگلیسی
⺠Hypothesis that mRNA molecules can have potent adjuvant effects in DNA vaccination was tested in vitro and in mice. ⺠RNA CpG and dsRNA motifs were incorporated into the transcribed region of pVAX1 DNA expressing M. leprae hsp65. ⺠Inserted immunostimulatory motifs resulted in substantially enhanced Th1 and cellular immune responses in mice. ⺠Inserted immunostimulatory motifs also enhanced significantly the therapeutic effect of DNA vaccine in mice that had been infected by aerosol with H37Rv.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 29, Issue 44, 13 October 2011, Pages 7624-7630
Journal: Vaccine - Volume 29, Issue 44, 13 October 2011, Pages 7624-7630
نویسندگان
Juan Wu, Hui Ma, Qing Qu, Wen-Jiang Zhou, Yu-Ping Luo, Harry Thangaraj, Dougtas B. Lowrie, Xiao-Yong Fan,