A novel, broad spectrum therapeutic HPV vaccine targeting the E7 proteins of HPV16, 18, 31, 45 and 52 that elicits potent E7-specific CD8T cell immunity and regression of large, established, E7-expressing TC-1 tumors

► HPV infection is associated with cervical and a number of other cancers. ► CD8 T cells specific to HPV E7 can cause tumors to regress in preclinical models. ► Pentarix is a therapeutic vaccine directed against 5 strains of HPV. ► Pentarix elicits strong CD8 immunity against HPV.