کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10970488 | 1103170 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combined virus-like particle-based polyepitope DNA/protein HIV-1 vaccine
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
We have previously described designing of polyepitope immunogens TBI and TCI, to stimulate the humoral and cellular immune responses to HIV-1. Here, immunogens TBI and TCI were used to create new vaccine construct named CombiHIVvac (Combined HIV-1 vaccine). CombiHIVvac is a virus-like particles (VLP) containing the DNA vaccine pcDNA-TCI as a core encapsulated within a spermidine-polyglucin-TBI conjugate. The immunogenic and toxic properties of the candidate vaccine CombiHIVvac have been studied. CombiHIVvac induces a strong humoral and CTL responses in mice; the antibodies are highly specific and are able to neutralize HIV-1 in vitro. Preclinical study demonstrated that CombiHIVvac does not cause long-term changes in physiological, biochemical and morphological parameters in immunized animals and thus can be recommended for clinical trials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 21, 22 May 2007, Pages 4312-4323
Journal: Vaccine - Volume 25, Issue 21, 22 May 2007, Pages 4312-4323
نویسندگان
Larisa I. Karpenko, Alexander A. Ilyichev, Alexey M. Eroshkin, Leonid R. Lebedev, Roman V. Uzhachenko, Nadezhda A. Nekrasova, Olga A. Plyasunova, Pavel A. Belavin, Sergei V. Seregin, Nadezhda K. Danilyuk, Boris N. Zaitsev, Elena D. Danilenko,