کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11019349 1718113 2018 43 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bile acid regulation: A novel therapeutic strategy in non-alcoholic fatty liver disease
ترجمه فارسی عنوان
تنظیم اسید روغنی: یک استراتژی جدید درمان در بیماری کبدی چربی غیر الکلی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive fat deposition in the liver in the absence of significant alcohol consumption. Dysregulated bile acid (BA) metabolism is an important indicator in the pathology of NAFLD, which could progress into more severe forms of liver injury. Lipid metabolism, immune environment and intestinal bacteria are all affected by dysregulated BA metabolism directly, but the mechanisms remain unclear. Several drug candidates that target BA metabolism, either used alone or in combination with other agents, are currently under development for treatment of NAFLD. Here, we summarize the relationship of dysregulated BA metabolism and NAFLD, discuss the effects and mechanisms of dysregulated BAs-induced lipid metabolism disorder. Challenges in developing novel treatments are also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 190, October 2018, Pages 81-90
نویسندگان
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