Chemiluminescent lateral-flow immunoassays by using in-situ synthesis of CdS NW photosensor

• A hypersensitive CdS nanowire (NW) photosensor was fabricated by the in-situ synthesis.
• The in-situ synthesis involved direct synthesis of CdS NWs on interdigitated electrodes.
• In-situ synthesized NW photosensor could highly enhance sensitivity and reproducibility.
• The NW photosensor was applied to the chemiluminescent lateral flow immunoassay.
• The medical diagnosis of the hepatitis B surface antigen (hHBsAg) was demonstrated.

A hypersensitive CdS nanowire (NW) photosensor was fabricated by an in-situ synthesis process that involved the direct synthesis of CdS NWs on an interdigitated electrode (IDE). Analysis of the photoresponse properties showed that the newly synthesized photosensor had enhanced sensitivity and a highly reproducible photoresponse compared to photosensors prepared from CdS NW suspensions. The NW photosensor was applied to measure the chemiluminescence of luminol, and the sensitivity was compared to a commercial photosensing system. Finally, the feasibility of the CdS NW photosensor for the application to the medical diagnosis of the human hepatitis B surface antigen (hHBsAg) was demonstrated using a lateral-flow immunoassay with a chemiluminescent signal band.

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