Application of Capillary Electrophoresis in Enzyme Inhibitors Screening

Capillary electrophoresis plays an irreplaceable role in the field of enzyme inhibitors screening with unique features of high-efficiency separation, short analysis time, minimal sample consumption, high sensitivity, ease to realize automatization etc. This review gives an overview of the applications of capillary electrophoresis in the field of enzyme inhibitors screening, and summarizes both the widely used off-line (pre-capillary) enzyme assay and on-line (in-capillary) enzyme assay. Finally, some future trends are briefly addressed.

Owing to its unique advantages such as short analysis time, minimal sample consumption, ease of automatization and the high-efficiency separation mechanism, capillary electrophoresis are widely applied in enzyme inhibitors screening by pre-capillary and in-capilalry enzyme assay. This review summarized the recent progress and prospected the development trend of capillary electrophoresis in the field of enzyme inhibitors screening.Figure optionsDownload as PowerPoint slide