Advance in Analysis and Detection Technologies for Phospholipidomics

Phospholipids, the principal constituents of cell membranes, has very important physiological functions and is closely related to human health and diseases. Therefore, comprehensive analysis of phospholipids is essential to enhance our understanding of function of phospholipids in disease process. Phospholipidomics is a phospholipids-targeted metabolomic approach which focuses on comprehensive qualitation and quantitation of phospholipids in biological system. Phospholipidomics study is carried out by the analysis and detection techniques involved in sample preparation, separation, qualitation and quantitation and data mining. In this paper, the analysis and detection methods for phospholipidomics are reviewed, providing a valuable reference for developing stable, reliable, high sensitivity, high resolution and high throughput platform techniques for phospholipidomics. The integrated investigation of phospholipidomics and other omics is proposed to promote the further development of analytical bioscience.

The advances and development trends in the analysis and detection technologies involved in sample preparation, separation, qualitation and quantitation and data mining for phospholipids-targeted analysis are presented in this paper, providing a valuable reference for developing stable, reliable, high sensitivity, high resolution, and high throughput platform techniques for phospholipidomics.Figure optionsDownload as PowerPoint slide