کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1211347 1493760 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of structural and interfacial properties of microemulsion eluent on chromatographic separation of simvastatin and its impurities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Influence of structural and interfacial properties of microemulsion eluent on chromatographic separation of simvastatin and its impurities
چکیده انگلیسی

In order to calculate the structural and compositional characteristics of microemulsions, used as eluents in the investigation of HPLC separation of simvastatin and its six impurities, predictive molecular thermodynamic approach is developed. For calculating fundamental interfacial properties of microemulsions, from pure component properties, the lattice fluid self-consistent field theory (SCF), in conjunction with new classical thermodynamic expressions, was applied. Calculation of predicted radii (PR), area per surfactant (ApS) and film thickness (FT), as well as is interfacial tension and bending moment enabled better understanding of separation of such a complex mixture. The microemulsion, which contained 1% (w/w) of diisopropyl ether, 2% (w/w) of sodium dodecyl sulphate (SDS), 6.6% (w/w) of co-surfactant such as n-butanol and 90.4% (w/w) of aqueous 25 mM disodium phosphate pH 7.0 enabled appropriate chromatographic separation between investigated compounds. It has been proved that this microemulsion had the smallest droplet radii and film thickness, which enabled optimal separation. Also the interfacial tension is the smallest, so the free energy change associated with dispersing the drops favoured a large number of small droplets. Hydrophobic interactions between solutes and stationary phase, as well as the microstructural characteristics of microemulsion eluents had a significant influence on chromatographic behavior of simvastatin and its six impurities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1131, Issues 1–2, 27 October 2006, Pages 67–73
نویسندگان
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