Forced degradation and impurity profiling: Recent trends in analytical perspectives

• Analytical trends for forced degradation and impurity profiling during 2008–2012.
• Yearly-wise discussion of impurity and degradation studies.
• Maximum use of isocratic elution and C18 columns.
• Exploration of therapeutic drug category in various matrixes.
• Quick reference guidance for forced degradation and impurity related research.

This review describes an epigrammatic impression of the recent trends in analytical perspectives of degradation and impurities profiling of pharmaceuticals including active pharmaceutical ingredient (API) as well as drug products during 2008–2012. These recent trends in forced degradation and impurity profiling were discussed on the head of year of publication; columns, matrix (API and dosage forms) and type of elution in chromatography (isocratic and gradient); therapeutic categories of the drug which were used for analysis. It focuses distinctly on comprehensive update of various analytical methods including hyphenated techniques for the identification and quantification of thresholds of impurities and degradants in different pharmaceutical matrices.

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