کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1222948 | 967875 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques](/preview/png/1222948.png)
A comprehensive overview is presented of currently known phase I metabolites of tamoxifen consisting of their systematic name and molecular structure. Reference standards are utilized to elucidate the MSn fragmentation patterns of these metabolites using a linear ion trap mass spectrometer. UV-absorption spectra are recorded and absorption maxima are defined.Serum extracts from ten breast cancer patients receiving 40 mg tamoxifen once daily were qualitatively analyzed for tamoxifen phase I metabolites using a liquid chromatography–tandem mass spectrometry set-up. In total, 19 metabolites have been identified in these serum samples. Additionally a synthetic method for the preparation of the putative metabolite 3′,4′-dihydroxytamoxifen is described.
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 55, Issue 3, 1 June 2011, Pages 518–526