کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1223616 | 967896 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gas chromatographic–mass spectrometric analysis of d-limonene in human plasma
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Gas chromatographic–mass spectrometric analysis of d-limonene in human plasma Gas chromatographic–mass spectrometric analysis of d-limonene in human plasma](/preview/png/1223616.png)
چکیده انگلیسی
d-Limonene shows carminative and cholagogue effects and is used in treatment of gallstone, cholecystitis and angiocholitis. A simple method was developed to determine the concentration of d-limonene in human plasma. d-Limonene and internal standard (naphthalane, C10H18) were extracted with n-hexane and then injected to GC–MS. Calibration curves were linear (r = 0.9990, n = 6) in the range of 2–500 ng/ml for d-limonene in human plasma. Limit of detection and quantification were 0.5 and 2 ng/ml, respectively. This rapid and specific method was applied to the clinical pharmacokinetic investigation of d-limonene.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 44, Issue 5, 3 September 2007, Pages 1095–1099
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 44, Issue 5, 3 September 2007, Pages 1095–1099
نویسندگان
Shurong Wang, Yu Chen, Zhaoxia Gao, Meijin Xiong, Zhirong Zhong, Liming Ye,