کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1223874 | 967903 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HPLC-UV determination of metformin in human plasma for application in pharmacokinetics and bioequivalence studies
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: HPLC-UV determination of metformin in human plasma for application in pharmacokinetics and bioequivalence studies HPLC-UV determination of metformin in human plasma for application in pharmacokinetics and bioequivalence studies](/preview/png/1223874.png)
چکیده انگلیسی
In this study, a simple, rapid and sensitive HPLC method with UV detection is described for determination of metformin in plasma samples from bioequivalence assays. Sample preparation was accomplished through protein precipitation with acetonitrile and chromatographic separation was performed on a reversed-phase phenyl column at 40 °C. Mobile phase consisted of a mixture of phosphate buffer and acetonitrile at flow rate of 1.0 ml/min. Wavelength was set at 236 nm. The method was applied to a bioequivalence study of two drug products containing metformin, and allowed determination of metformin at low concentrations with a higher throughput than previously described methods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 46, Issue 1, 7 January 2008, Pages 143–147
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 46, Issue 1, 7 January 2008, Pages 143–147
نویسندگان
Valentina Porta, Simone Grigoleto Schramm, Eunice Kazue Kano, Eunice Emiko Koono, Yara Popst Armando, Kazuo Fukuda, Cristina Helena dos Reis Serra,