New potentiometric sensors based on selective recognition sites for determination of ephedrine in some pharmaceuticals and biological fluids

► Novel ISEs for batch and continuous determination of ephedrine are described. ► Triacetyl-β-cyclodextrin as a neutral ionophore in a plasticized PVC matrix is used. ► Carboxylated PVC as both a plastic matrix and an ion exchanger is also used. ► Detailed characterization and validation of the assay method were reported.