Advances in and prospects of microchip liquid chromatography

• Advances in on-chip microfluidic LC columns are described.
• Stationary-phase supports for chip-LC include particles, monoliths, and pillar arrays.
• Different substrate materials and selectivities can be used for specific separations.

This study focuses on recent advances (from January 2013 through April 2015) in microfluidic liquid chromatography. Articles published during this period are organized by the type of stationary-phase support focusing on device fabrication, column preparation, and specific applications. In addition, a comprehensive table comparing chromatographic figures of merit for this study is provided in Appendix A as a reference for readers.