کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1248377 970428 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid-phase microextraction. How far are we from clinical practice?
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Solid-phase microextraction. How far are we from clinical practice?
چکیده انگلیسی

The current review briefly discusses the future development of solid-phase microextraction (SPME) and its potential application in the field of clinical medicine, including pharmacokinetic studies, therapeutic drug monitoring, biomarker discovery, and targeted and untargeted metabolomics. We also discuss aspects of automation and high-throughput analysis as major requirements of daily clinical practice. We give examples of clinically-validated applications of SPME and point out the regulatory restrictions limiting some in-vivo SPME studies. We briefly review the current state of progress in this extraction technique in the context of its future application in medical research and laboratory testing, including new directions (i.e. personalized medicine).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 30, Issue 9, October 2011, Pages 1505–1512
نویسندگان
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