The changing role of NMR spectroscopy in off-line impurity identification: A conceptual view

In spite of its supreme capabilities in structure elucidation, NMR spectroscopy has played relatively little role in the identification of unknown trace impurities. However, recent advancements have resulted in a massive leap in the sensitivity of NMR detection, particularly with dedicated cold probes that offer a user-friendly solution to investigating the structure of minute samples.