Analytical technologies for metabonomics and metabolomics, and multi-omic information recovery

Metabonomics can now be regarded as a central pillar in top-down systems biology. We summarize methods for generating and interpreting metabolic profiles based on nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS) and multivariate chemometrics. We describe recent developments for information recovery from complex data sets, including integration of NMR and MS results and trans-omics correlations.