کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1252043 1496317 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
n−3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
n−3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization
چکیده انگلیسی

It is now well established that dietary lipids are incorporated into macrophage and T-cell membrane microdomains, altering their structure and function. Within cell membranes, there are specific detergent-resistant domains in which key signal transduction proteins are localized. These regions are classified as “lipid rafts”. Rafts are composed mostly of cholesterol and sphingolipids and therefore do not integrate well into the fluid phospholipid bilayers causing them to form microdomains. Upon cell activation, rafts compartmentalize signal-transducing molecules, thus providing an environment conducive to signal transduction. In this review, we discuss recent novel data describing the effects of n−3 PUFA on alterations in the activation and functions of macrophages and T-cells. We believe that the modifications in these two disparate immune cell types are linked by fundamentally similar changes in membrane lipid composition and transmembrane signaling functions. We conclude that the outcomes of n−3 PUFA-mediated immune cell alterations may be beneficial (e.g., anti-inflammatory) or detrimental (e.g., loss of microbial immunity) depending upon the cell type interrogated.


► Dietary fatty acids alter membrane-mediated macrophage functions and promote the pathogenesis and immune control of infectious diseases.
► n−3 PUFA uniquely affect membrane composition in J774 and fat-1 macrophages.
► PUFA alter the dynamic organization of the lymphocyte plasma membrane and modulate downstream cell signaling.
► The accumulation of lipid rafts in cell lines may be fundamentally distinct from primary cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 164, Issue 7, October 2011, Pages 626–635
نویسندگان
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