Triorganotin(IV) complexes with o-substituted arylhydroxamates: Synthesis, spectroscopic characterization, X-ray structures and in vitro cytotoxic activities

• Six new triphenyltin(IV) hydroxamates were synthesized.
• The complexes were characterized by CHNS, IR, TGA, NMR and X-ray.
• The NMR and X-ray studies were in full concurrence with the IR studies.
• The structures of the complexes adopted a five coordination geometry at tin.
• The complexes demonstrated promising antiproliferative activities at μM concentration.

Six new triorganotin(IV) complexes with six different RN-2-X-benzohydroxamic acid ligands having general formula R′C(O)N(RN)OH (R′ = alkyl/aryl; RN = alkyl/aryl or H), (X = –I, –NO2, –OCH3, –Br and R = –CH3, –C6H5 and –C6H4–CH3), were prepared by condensation method with the respective organotin(IV) chlorides using a stoichiometric ratio of 1:1. The bonding and coordination behaviour of these complexes were investigated on the basis of FT-IR, multinuclear 1H, 13C and 119Sn NMR spectroscopies. Complexes (1) and (3) crystallize in the orthorhombic P2(1)2(1)2(1) space group and complex (2) crystallizes in the triclinic P-1 space group whereas complex (4) crystallizes in the monoclinic P2(1)/c space group. The tested triphenyltin(IV) complexes showed significant cytotoxicities, higher than doxorubicin toward K-562, Jurkat, HepG2 and L929 cells.

Six triphenyltin(IV) complexes prepared with the respective triorganotin(IV) chlorides and were investigated on the basis of CHN, TGA, FT-IR, NMR and X-ray studies. Complexes (1) and (3) crystallize in the orthorhombic and (2) in the triclinic whereas (4) in the monoclinic space group. These compounds demonstrated promising cytotoxic activities.Figure optionsDownload as PowerPoint slide