کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1324190 | 977327 | 2010 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Isotopomeric diols by “one-pot” Ru-catalyzed homogeneous hydrogenation of dicarboxylic acids Isotopomeric diols by “one-pot” Ru-catalyzed homogeneous hydrogenation of dicarboxylic acids](/preview/png/1324190.png)
The “one-pot” homogeneous hydrogenation of γ-butyrolactone and succinic or fumaric acid to 1,4-butandiol, have been successfully realized in the presence of the catalytic system [Ru(acac)3]/triphos] [triphos:MeC(CH2PPh2)3]. The influence of some reaction parameters on the regioselectivity and the rate of the reaction were investigated. The study was then extended to the “one-pot” synthesis of isotopomeric 1,4-butandiols by deuteration of the appropriate substrates in a deuterated solvent. 1,4-butandiol-d8, which was fully characterized, was obtained with 96% yield and 100% isotopomeric selectivity. A mechanism was proposed to rationalize the role of catalyst, solvent and deuterium distribution.
Hydrogenation of 1,4-dicarboxylic acids gives 1,4-butandiol using a ruthenium catalyst, triphos ligand and methanol. The one pot synthesis of isotopomeric butandiols containing 6, 8 or 10 deuterium atoms was easily achieved with this catalytic system.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 695, Issue 9, 1 May 2010, Pages 1314–1322