کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371637 981849 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents
چکیده انگلیسی

A simple and rapid NMR method is described to determine the log P of pharmaceutical agents. This method is highly versatile and efficient, because it does not require the use of deuterated solvents or the addition of any internal/external standards to the sample. We demonstrate that log P can be accurately measured using NMR for pharmaceutical agents with known log P values. Our proposed method is made possible by the combination of state-of-the-art NMR techniques including the solvent concentration reference and robust solvent suppressions.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 22, 15 November 2010, Pages 6712–6715
نویسندگان
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